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Decoding the Neuroimmune Synapse in Lewy Body Dementia: Genetic risk convergence on CD4⁺ T cell–neuron interactions
Lewy Body Dementia (LBD) is characterized by the accumulation of alpha-synuclein and chronic neuroinflammation. Despite the identification of risk loci by genome-wide association studies (GWAS), the functional convergence of these genetic factors upon cellular interactions remains largely unmapped. This study hypothesizes that LBD pathogenesis is driven by a genetically primed neuroimmune synapse where antigen-experienced T
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Unraveling the genetic architecture of autism: a multi-omic approach towards mirror neurons
Background: Autism spectrum disorder (ASD) affects approximately 1% of the global pediatric population, characterized by persistent deficits in social communication, restricted behavioral patterns, and impaired socio-communicative signal processing. The mirror neuron system, recognized as fundamental for imitation processes, theory of mind, and social cognition, exhibits systematic dysfunctions in individuals with ASD. However, the genetic architecture